Current Medical Diagnosis & Treatment, 60th Edition PDF by Maxine A. Papadakis, Stephen J. McPhee, and Michael W. Rabow

By

Current Medical Diagnosis & Treatment, Sixtieth Edition

By Maxine A. Papadakis, Stephen J. McPhee, and Michael W. Rabow

Current Medical Diagnosis & Treatment, 60th Edition

Contents

Authors

Preface

1. Disease Prevention & Health Promotion 1

Michael Pignone, MD, MPH, & Rene Salazar, MD

2. Common Symptoms 16

Paul L. Nadler, MD, & Ralph Gonzales, MD, MSPH

3. Preoperative Evaluation & Perioperative Management 44

Hugo Q. Cheng, MD

4. Geriatric Disorders 54

Michael Harper, MD, C. Bree Johnston,

MD, MPH, & C. Seth Landefeld, MD

5. Palliative Care & Pain Management 70

Michael 1/1/. Rabow, MD, Steven Z. Pantilat, MD,

Ann Cai Shah, MD, Lawrence Poree, MD, MPH, PhD, & Scott Steiger, MD

6. Dermatologic Disorders 102

Kanade Shinkai, MD, PhD, & Lindy P. Fox, MD

7. Disorders of the Eyes & Lids 173

Jacque L. Duncan, MD, Neeti B. Parikh, MD, &

Gerami D. Seitzman, MD

8. Ear, Nose, & Throat Disorders 210

Lawrence R. Lustig, MD, & Joshua S. Schindler, MD

9. Pulmonary Disorders 251

Asha N. Chesnutt, MD, Mark S. Chesnutt, MD,

Niall T. Prendergast, MD, &

Thomas J. Prendergast, MD

10. Heart Disease 334

Thomas M. Bashore, MD, Christopher B. Granger,

MD, Kevin P. Jackson, MD, & Manesh R. Patel, MD

11. Systemic Hypertension 453

Michael Sutters, MD, MRCP (UK)

12. Blood Vessel & Lymphatic Disorders 485

Warren J. Gasper, MD, James C. lannuzzi, MD, MPH, & Meshell D. Johnson, MD

13. Blood Disorders 512

Lloyd E. Damon, MD, & Charalambos Babis

Andreadis, MD, MSCE

14. Disorders of Hemostasis, Thrombosis, & Antithrombotic Therapy 558

Andrew D. Leavitt, MD, Erika Leemann Price, MD,

MPH, & Tracy Minichiello, MD

15. Gastrointestinal Disorders 592

Kenneth R. McQuaid, MD

16. Liver, Biliary Tract, & Pancreas Disorders 693

Lawrence S. Friedman, MD

17. Breast Disorders 758

Armando E. Giuliano, MD, FACS, FRCSEd, &

Sara A. Hurvitz, MD, FACP

18. Gynecologic Disorders 785

Jason Woo, MD, MPH, FACOG, &

Jill Long, MD, MPH, MHS, FACOG

19. Obstetrics & Obstetric Disorders 820

Vanessa L. Rogers, MD, & Scott W. Roberts, MD

20. Rheumatologic, Immunologic, & Allergic Disorders 849

Jinoos Yazdany, MD, MPH, Rebecca Manno, MD,

MHS, David B. Hellmann, MD, MACP, & John B. Imboden Jr., MD

21. Electrolyte & Acid-Base Disorders 909

Nayan Arora, MD, & J. Ashley Jefferson, MD

22. Kidney Disease 938

Tonja C. Dirkx, MD, & Tyler B. Woodell, MD, MCR

23. Urologic Disorders 980

Mathew Sorensen, MD, MS, FACS, Thomas J. Walsh,

MD, MS, & Kevin A. Ostrowski, MD

24. Nervous System Disorders 1005

Vanja C. Douglas, MD, &

Michael J. Aminoff, MD, DSc, FRCP

25. Psychiatric Disorders 1082

Kristin S. Raj, MD, Nolan Williams, MD, &

Charles DeBattista, DMH, MD

26. Endocrine Disorders 1138

Paul A. Fitzgerald, MD

27. Diabetes Mellitus & Hypoglycemia 1242

Umesh Moshorani, MB, BS, MRCP (UK)

28. Lipid Disorders 1288

Michael J. Blaha, MD, MPH

29. Nutritional Disorders 1299

Katherine H. Sounders, MD, &

Leon I. lgel, MD, FACP, FTOS

30. Common Problems in lnfedious Diseases & Antimicrobial Therapy 1320

Peter V. Chin-Hong, MD, & Joseph Guglielmo, PharmD

31. HIV Infection & AIDS 1361

Mitchell H. Katz, MD

32. Viral & Rickettsial Infections 1403

Eva Clark. MD, PhD, & Wayne X. Shandera, MD

33. Baderlal & Chlamydlallnfectlons 1490

Bryn A. Boslett, MD, & Brion S. Schwartz, MD

34. Spirochetal Infections 1535

Susan S. Philip, MD, MPH

35. Protozoal & Helminthic Infections 1552

Philip J. Rosenthal, MD

36. Mycotic Infections 1593

Stacey R. Rose, MD, & Richard J. Hamill, MD

37. Disorders Related to Environmental Emergencies 1608

Jacqueline A. Nemer, MD, FACEP, &

Marianne A. Juarez. MD

38. Poisoning 1624

Craig Smollin, MD, & Kent R. Olson, MD

39. Cancer 1654

Sunny Wang, MD, Tiffany 0. Dea, PharmD, BCOP,

Patricio A. Cornett, MD, Lawrence S. Friedman, MD,

Carling Ursem, MD, Kenneth R. McQuaid, MD, &

George R. Schade, MD

40. Genetic & Genomic Disorders 1721

Reed E. Pyeritz, MD, PhD

41. Sports Medicine & Outpatient Orthopedics 1730

Anthony Luke, MD, MPH, & C. Benjamin Mo, MD

42. Sexual & Gender Minority Health 1765

Juno Obedln-Mallver, MD, MPH, MAS,

Patricio A. Robertson, MD, Kevin L. Arc/, MD, MPH,

Kenneth H. Moyer, MD, & Madeline B. Deutsch, MD, MPH

e1. Anti-lnfedive Chemotherapeutic &

Antibiotic Agents Online*

Katherine Gruenberg, PharmD, &

Joseph Guglielmo, PhormD

e2. Diagnostic Testing & Medical

Decision Making

Chuonyi Mark Lu, MD

e3. Information Technology in Patient

Online*

Care Online*

Russ Cue/no, MD, MS

e4. Integrative Medicine

Dorshon Mehta, MD, MPH

e5. Podiatric Disorders

Online*

Online*

Monara Dlnl, DPM, & Charles B. Parks, DPM

e6. Women’s Health Issues Online*

Brigid Dolan, MD, MEd, & Judith Walsh, MD, MPH

e7. Appendix: Therapeutic Drug Monitoring,

Laboratory Reference Intervals, &

Pharmacogenetic Tests Online*

Chuanyi Mark Lu, MD

Index 1787

Preface

Current Medical Diagnosis & Treatment 2021 (CMDT 2021) is the 60th edition of this single-source reference for practitioners in both hospital and ambulatory settings. The book emphasizes the practical features of clinical diagnosis and patient management in all fields of internal medicine and in specialties of interest to primary care practitioners and to subspecialists who provide general care.

Our students have inspired us to look at issues of race and justice, which surely impact peoples health. We have therefore reviewed the content of our work to ensure that it contains the dignity and equality that every patient deserves.

Intended Audience For CMDT

House officers, medical students, and all other health professions students will find the descriptions of diagnostic and therapeutic modalities, with citations to the current literature, of everyday usefulness in patient care. Internists, family physicians, hospitalists, nurse practitioners, physician assistants, and all primary care providers will appreciate CMDT as a ready reference and refresher text. Physicians in other specialties, pharmacists, and dentists will find the book a useful basic medical reference text. Nurses, nurse practitioners, and physician assistants will welcome the format and scope of the book as a means of quickly referencing medical diagnosis and treatment modalities. Patients and their family members who seek information about the nature of specific diseases and their diagnosis and treatment may also find this book to be a valuable resource.

New In This Edition Of CMDT

  • INNOVATIVE TABLE highlighting the “Year in Review: Key Clinical Updates in CMDT 2021,” individually listed with page numbers and reference citations, for easy access to significant changes in this edition
  • New section on SARS-CoV-2 virus and COVID-19 infection
  • Extensive revision of the Viral & Rickettsial Infections chapter, including new section on acute flaccid myelitis as well as updates on measles, mumps, and Zika virus
  • 140 NEW online images in the Heart Disease, Gastrointestinal Disorders, and Cancer chapters
  • Addition of the 2019 European guidelines for treating pulmonary embolism
  • New table outlining agents to consider for reversing anticoagulant effect during life-threatening bleeding based on the Anticoagulation Forum and American Society of Hematology 2019 guidelines
  • Bedaquiline considered first-line medication for multidrug-resistant tuberculosis
  • Lefamulin, a new commercially available medication for treating community-acquired bacterial pneumonia
  • New information on the combination of emtricitabine/tenofovir alafenamide as antiretroviral treatment for preexposure prophylaxis among men
  • A two-drug regimen, dolutegravir plus lamivudine, included in the top recommended HIV antiretroviral regimens
  • Recommendation from the Advisory Committee on Immunization Practices for shared clinical decision-making regarding HPV vaccination for adults aged 26-45 years
  • Substantial revision of the Sexual & Gender Minority Health chapter
  • Bempedoic acid, a new FDA-approved pharmacologic option for lowering LDL cholesterol in patients who cannot tolerate statins
  • FDA approval of various closed loop systems that adjust basal insulin delivery for diabetic patients
  • Eculizumab, a newly FDA-approved medication for both myasthenia gravis and neuromyelitis optica
  • FDA approval of lasmiditan, a new pharmacologic option that can safely be given to migraine sufferers with cardiovascular risk factors
  • The sodium-glucose linked transporter (SGLT) inhibitors slow progression of early diabetic nephropathy in addition to their having cardioprotective effects
  • The US Preventive Services Task Force recommendation for hepatitis C screening of asymptomatic adults between ages 18 and 79 years
  • FDA approval of adjuvant trastuzumab emtansine for patients with HER2-positive breast cancer with residual disease after standard trastuzumab-containing neoadjuvant therapy
  • Data from HER2CLIMB, a phase III trial, expected to lead to FDA approval of a new therapy for breast cancer patients with pretreated HER2-positive advanced disease
  • Promising results from phase 3 clinical trials of gene therapy for hemophilia A and B
  • Information on bremelanotide, a second FDA-approved medication for hypoactive sexual desire disorder in premenopausal women
  • Mepolizumab, newly FDA approved for the treatment of eosinophilic granulomatosis with polyangiitis

Outstanding Features Of CMDT

  • Medical advances up to time of annual publication
  • Detailed presentation of internal medicine disciplines, plus primary care topics in gynecology, obstetrics, dermatology, ophthalmology, otolaryngology, psychiatry, neurology, toxicology, urology, geriatrics, orthopedics, womens health, sexual and gender minority health, preventive medicine, and palliative care
  • Concise format, facilitating efficient use in any practice setting
  • More than 1000 diseases and disorders
  • Annual update on HIV/AIDS and other newly emerging infections
  • Specific disease prevention information
  • Easy access to medication dosages, with trade names indexed and costs updated in each edition
  • Recent references, with unique identifiers (PubMed, PMID numbers) for rapid downloading of article abstracts and, in some instances, full-text reference articles

E-CHAPTERS, CMDT ONLINE, & AVAILABLE APPS

Seven e-chapters listed in the Table of Contents can be accessed at www.AccessMedicine.com/CMDT. These online-only chapters (available without need for subscription) include

  • Anti-Infective Chemotherapeutic & Antibiotic Agents
  • Diagnostic Testing & Medical Decision Making
  • Information Technology in Patient Care
  • Integrative Medicine
  • Podiatric Disorders
  • Womens Health Issues
  • Appendix: Therapeutic Drug Monitoring, Laboratory Reference Intervals, & Pharmacogenetic Tests

Institutional or individual subscriptions to AccessMedicine also have full electronic access to CMDT 2021. Subscribers to CMDT Online receive full electronic access to CMDT 2021 as well as

  • An expanded, dedicated media gallery
  • Quick Medical Diagnosis & Treatment (QMDT)—a concise, bulleted version of CMDT 2021
  • Guide to Diagnostic Tests—for quick reference to the selection and interpretation of commonly used diagnostic tests
  • CURRENT Practice Guidelines in Primary Care—delivering concise summaries of the most relevant guidelines in primary care
  • Diagnosaurus—consisting of 1000+ differential diagnoses

CMDT 2021, QMDT, Guide to Diagnostic Tests, and Diagnosaurus are also available as individual apps for your smartphone or tablet and can be found in the Apple App Store and Google Play.

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