Casarett & Doull’s Essentials of Toxicology, Fourth Edition
By Curtis D Klaassen and John B Watkins III
Contents:
Contributors
Preface
UNIT 1
General Principles Of Toxicology
- The Evolving Journey of Toxicology: A Historical Glimpse
Philip Wexler and Antoinette N. Hayes
- Principles of Toxicology
Lauren M. Aleksunes and David L. Eaton
- Mechanisms of Toxicity
Lois D. Lehman-McKeeman
- Risk Assessment
Elaine M. Faustman
UNIT 2
Disposition Of Toxicants
- Absorption, Distribution, and Excretion of Toxicants
Angela L. Slitt
- Biotransformation of Xenobiotics
Andrew Parkinson, Brian W. Ogilvie, David B. Buckley, Faraz Kazmi,
and Oliver Parkinson
- Toxicokinetics
Kannan Krishnan
UNIT 3
Non-Organ-Directed Toxicity
- Chemical Carcinogenesis
James E. Klaunig and Zemin Wang
- Genetic Toxicology
Joanna Klapacz and B. Bhaskar Gollapudi
- Developmental Toxicology
John M. Rogers
UNIT 4
Target Organ Toxicity
- Toxic Responses of the Blood
Martyn T. Smith and Cliona M. McHale
- Toxic Responses of the Immune System
Barbara L.F. Kaplan, Courtney E.W. Sulentic, Helen G. Haggerty,
Michael P. Holsapple, and Norbert E. Kaminski
- Toxic Responses of the Liver
Robert A. Roth, Hartmut Jaeschke, and James P. Luyendyk
- Toxic Responses of the Kidney
Rick G. Schnellmann
- Toxic Responses of the Respiratory System
George D. Leikauf
- Toxic Responses of the Nervous System
Virginia C. Moser, Michael Aschner, Jason R. Richardson, Aaron B.
Bowman, and Rudy J. Richardson
- Toxic Responses of the Cornea, Retina, and Central Visual System
Donald A. Fox and William K. Boyes
- Toxic Responses of the Heart and Vascular System
Matthew J. Campen
- Toxic Responses of the Skin
Donald V. Belsito
- Toxic Responses of the Endocrine System
Patricia B. Hoyer and Jodi A. Flaws
- Toxic Responses of the Reproductive System
Paul M.D. Foster and L. Earl Gray Jr.
UNIT 5
Toxic Agents
- Toxic Effects of Pesticides
Lucio G. Costa
- Toxic Effects of Metals
Alexander C. Ufelle and Aaron Barchowsky
- Toxic Effects of Solvents and Vapors
James V. Bruckner, S. Satheesh Anand, and D. Alan Warren
- Toxic Effects of Radiation and Radioactive Materials
David G. Hoel
- Toxic Effects of Plants and Animals
John B. Watkins, III
- Food Toxicology: Fundamental and Regulatory Aspects
Supratim Choudhuri
- Toxic Effects of Calories
Martin J.J. Ronis, Kartik Shankar, and Thomas M. Badger
- Nanoparticle Toxicology
David B. Warheit, Günter Oberdörster, Agnes B. Kane, Scott C.
Brown, Rebecca D. Klaper, and Robert H. Hurt
UNIT 6
Environmental Toxicology
- Ecotoxicology
Richard T. Di Giulio and Michael C. Newman
Daniel L. Costa and Terry Gordon
UNIT 7
Applications Of Toxicology
- Analytical and Forensic Toxicology
Bruce A. Goldberger, Dayong Lee, and Diana G. Wilkins
- Clinical Toxicology
Louis R. Cantilena Jr.
- Occupational Toxicology
Peter S. Thorne
Answers to Chapter Questions
Index
Preface
This fourth edition of Essentials of Toxicology condenses the principles and concepts of toxicology that were described in the ninth edition of Casarett & Doull’s Toxicology: The Basic Science of Poisons. Essentials of Toxicology succinctly defines the expansive science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action.
We greatly appreciate the authors who contributed to the ninth edition of Casarett & Doull’s Toxicology: The Basic Science of Poisons because their chapters in the parent text provided the foundation for this edition of Essentials of Toxicology. The book is organized into seven units: (1) General Principles of Toxicology, (2) Disposition of Toxicants, (3) Non-organ-directed Toxicity, (4) Target Organ Toxicity, (5) Toxic Agents, (6) Environmental Toxicology, and (7) Applications of Toxicology. Key points and review questions are provided for each chapter.
We trust that this book will assist students in undergraduate and graduate courses in toxicology, as well as students from other disciplines, to develop a strong foundation in the concepts and principles of toxicology. We invite readers to send us suggestions of ways to improve this text and we appreciate the thoughtful recommendations that we received on the last edition.
We particularly give a heartfelt and sincere thanks to our families for their love, patience, and support during the preparation of this book. The capable guidance and assistance of the McGraw-Hill staff are gratefully acknowledged. Finally, we thank our students for their enthusiasm for learning and what they have taught us during their time with us.
Curtis D. Klaassen
John B. Watkins III