Casarett & Doull’s Essentials of Toxicology, 4th Edition PDF by Curtis D Klaassen and John B Watkins III


Casarett & Doull’s Essentials of Toxicology, Fourth Edition

By Curtis D Klaassen and John B Watkins III

Casarett & Doull’s Essentials of Toxicology, 4th Edition





General Principles Of Toxicology

  1. The Evolving Journey of Toxicology: A Historical Glimpse

Philip Wexler and Antoinette N. Hayes

  1. Principles of Toxicology

Lauren M. Aleksunes and David L. Eaton

  1. Mechanisms of Toxicity

Lois D. Lehman-McKeeman

  1. Risk Assessment

Elaine M. Faustman


Disposition Of Toxicants

  1. Absorption, Distribution, and Excretion of Toxicants

Angela L. Slitt

  1. Biotransformation of Xenobiotics

Andrew Parkinson, Brian W. Ogilvie, David B. Buckley, Faraz Kazmi,

and Oliver Parkinson

  1. Toxicokinetics

Kannan Krishnan


Non-Organ-Directed Toxicity

  1. Chemical Carcinogenesis

James E. Klaunig and Zemin Wang

  1. Genetic Toxicology

Joanna Klapacz and B. Bhaskar Gollapudi

  1. Developmental Toxicology

John M. Rogers


Target Organ Toxicity

  1. Toxic Responses of the Blood

Martyn T. Smith and Cliona M. McHale

  1. Toxic Responses of the Immune System

Barbara L.F. Kaplan, Courtney E.W. Sulentic, Helen G. Haggerty,

Michael P. Holsapple, and Norbert E. Kaminski

  1. Toxic Responses of the Liver

Robert A. Roth, Hartmut Jaeschke, and James P. Luyendyk

  1. Toxic Responses of the Kidney

Rick G. Schnellmann

  1. Toxic Responses of the Respiratory System

George D. Leikauf

  1. Toxic Responses of the Nervous System

Virginia C. Moser, Michael Aschner, Jason R. Richardson, Aaron B.

Bowman, and Rudy J. Richardson

  1. Toxic Responses of the Cornea, Retina, and Central Visual System

Donald A. Fox and William K. Boyes

  1. Toxic Responses of the Heart and Vascular System

Matthew J. Campen

  1. Toxic Responses of the Skin

Donald V. Belsito

  1. Toxic Responses of the Endocrine System

Patricia B. Hoyer and Jodi A. Flaws

  1. Toxic Responses of the Reproductive System

Paul M.D. Foster and L. Earl Gray Jr.


Toxic Agents

  1. Toxic Effects of Pesticides

Lucio G. Costa

  1. Toxic Effects of Metals

Alexander C. Ufelle and Aaron Barchowsky

  1. Toxic Effects of Solvents and Vapors

James V. Bruckner, S. Satheesh Anand, and D. Alan Warren

  1. Toxic Effects of Radiation and Radioactive Materials

David G. Hoel

  1. Toxic Effects of Plants and Animals

John B. Watkins, III

  1. Food Toxicology: Fundamental and Regulatory Aspects

Supratim Choudhuri

  1. Toxic Effects of Calories

Martin J.J. Ronis, Kartik Shankar, and Thomas M. Badger

  1. Nanoparticle Toxicology

David B. Warheit, Günter Oberdörster, Agnes B. Kane, Scott C.

Brown, Rebecca D. Klaper, and Robert H. Hurt


Environmental Toxicology

  1. Ecotoxicology

Richard T. Di Giulio and Michael C. Newman

  1. Air Pollution

Daniel L. Costa and Terry Gordon


Applications Of Toxicology

  1. Analytical and Forensic Toxicology

Bruce A. Goldberger, Dayong Lee, and Diana G. Wilkins

  1. Clinical Toxicology

Louis R. Cantilena Jr.

  1. Occupational Toxicology

Peter S. Thorne

Answers to Chapter Questions



This fourth edition of Essentials of Toxicology condenses the principles and concepts of toxicology that were described in the ninth edition of Casarett & Doull’s Toxicology: The Basic Science of Poisons. Essentials of Toxicology succinctly defines the expansive science of toxicology, and includes important concepts from anatomy, physiology, and biochemistry to facilitate the understanding of the principles and mechanisms of toxicant action.

We greatly appreciate the authors who contributed to the ninth edition of Casarett & Doull’s Toxicology: The Basic Science of Poisons because their chapters in the parent text provided the foundation for this edition of Essentials of Toxicology. The book is organized into seven units: (1) General Principles of Toxicology, (2) Disposition of Toxicants, (3) Non-organ-directed Toxicity, (4) Target Organ Toxicity, (5) Toxic Agents, (6) Environmental Toxicology, and (7) Applications of Toxicology. Key points and review questions are provided for each chapter.

We trust that this book will assist students in undergraduate and graduate courses in toxicology, as well as students from other disciplines, to develop a strong foundation in the concepts and principles of toxicology. We invite readers to send us suggestions of ways to improve this text and we appreciate the thoughtful recommendations that we received on the last edition.

We particularly give a heartfelt and sincere thanks to our families for their love, patience, and support during the preparation of this book. The capable guidance and assistance of the McGraw-Hill staff are gratefully acknowledged. Finally, we thank our students for their enthusiasm for learning and what they have taught us during their time with us.

Curtis D. Klaassen
John B. Watkins III

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